![]() Okay, so proteins do important things within cells, and scientists want to understand these processes. Some research studies have proposed that NK cells lose their ability to produce these proteins as we age, so we could better understand how NK cells age by looking at the amount of proteins like perforin and granzymes inside a cell at different points throughout a person’s life. They do this by releasing toxic proteins called perforin (which form pores in the membrane of a target cell) and granzymes (proteins that flood into the cell through the holes made by perforin, and cause the target cell to undergo apoptosis or programmed cell death). ![]() For example, Natural Killer cells (or NK cells) are an important immune cell that roam around in our blood stream and kill cancerous or virally infected cells. The proteins that a cell is making at a given time can help us understand what the cell is doing or if it isn’t functioning properly and like I said before, this is really valuable information. Internal signaling proteins basically play a game of telephone to transmit that signal down to the nucleus, and the cell can respond to its environment by making new proteins or even breaking down proteins that are already present into their amino acid subunits. ![]() Receptor proteins on the surface of a cell allow it to understand what is happening in the local environment. So, learning about the internal workings of a cell is a really important task, and at the heart of all of these processes are proteins which are the “doers” of the cell. If they know how cells work on the inside, they can use this information to better treat, or potentially cure a wide range of diseases. For a cell to be able to accomplish important tasks like these, there is a lot that has to happen within the membrane, and scientists are really excited about uncovering what all of those internal cellular processes are. Your immune cells are roaming around looking for foreign pathogens, cells in your gut are helping you digest food, and right now the cells in your brain are trying to help you pay attention to this video. a chemical compound that can absorb and re-emit lightĮven though you can’t see it, the cells that make up your body are doing lots of important tasks that keep you alive.a large, “Y” shaped protein that binds directly to the Fc region of a primary antibody.a large, “Y” shaped protein that binds directly to one protein or antigen with high specificity.an aqueous solution that resists changes in pH when small amounts of acid or base are added.a microporous substance which binds proteins.a set of protein standards used to estimate the size of experimental protein samples run during gel electrophoresis.a medium for performing gel electrophoresis which contains long chains of amide groups. ![]() disrupting the molecular conformation of a protein.a molecule with polar and nonpolar components that disrupts the hydrophobic/hydrophilic interactions of biological substances (e.g.a technique used to assess the presence of post-translational modifications such as phosphates, lipids, or carbohydrate epitopes.a laboratory technique used to detect the presence of specific DNA sequence from a larger pool of DNA molecules.a laboratory technique used to detect the presence of specific RNA molecules from a larger pool of RNA.serine proteases released by cytotoxic T lymphocytes (CTLs) and natural killer cells (NK cells) that induce programmed cell death (apoptosis) in target cells.When released, perforin polymerizes and forms pores in the plasma membrane of a target cell a cytolytic protein produced by cytotoxic T lymphocytes (CTLs) and natural killer cells (NK cells).
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